| Cat. No. |
Product Name |
Information |
| PC-42696 |
PTP1B-IN-1
PTP1B inhibitor
|
PTP1B-IN-1 is a 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for design of protein tyrosine phosphatase-1B (PTP1B) inhibitor, shows weak inhibition for PTP1B with IC50 of 1.6 mM. |
| PC-27322 |
TAT-QFNP12
NDRG2-PPM1A inhibitor
|
TAT-QFNP12 is a peptide inhibitor of N-myc downstream-regulated gene 2 (NDRG2)-PPM1A interaction, blocks NDRG2-PPM1A binding and reduces Smad2/3 dephosphorylation, decreases astrocytic MMP-9 production and BBB disruption after subarachnoid hemorrhage (SAH). |
| PC-27292 |
DDO-4279
PP5 degrader
|
DDO-4279 is a selective serine/threonine phosphatase PP5 degrader with DC50 of 6.9 uM, selectively degrades PP5 via the ubiquitin-proteasome pathway, thereby downregulating PP5 substrate proteins PPARγ and GR. |
| PC-27250 |
PTPN22 inhibitor L-32
PTPN22 inhibitor
|
PTPN22 inhibitor L-32 is a potent, selective PTPN22 inhibitor with IC50 of 0.49 uM and Ki of 0.28 uM, >14-fold selective over other PTPs. |
| PC-27140 |
EYA2-IN-1
EYA2 inhibitor
|
EYA2-IN-1 is a specific, small molecule allosteric EYA2 inhibitor with IC50 of 0.36 uM, inhibits cell growth of medulloblastoma cell line D458 with GI50 of 1.9 uM. |
| PC-27138 |
ETC-616
EYA2 inhibitor
|
ETC-616 is a small molecule allosteric Eyes absent homolog 2 (EYA2) inhibitor. |
| PC-27109 |
LXQ-87
PTP1B inhibitor
|
LXQ-87 is a selective, orally active, allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B/PTPN1) with IC50 of 1.06 uM, displays excellent selectivity over TCPTP and SHP-2. |
| PC-27065 |
SHP2 inhibitor 17g
SHP2 inhibitor
|
SHP2 inhibitor 17g is a potent and selective allosteric SHP2 inhibitor with IC50 of 49 nM (SHP2 WT). |
| PC-27043 |
DBK-766
PP2A activator
|
DBK-766 is a nonfunctional small molecule activator of PP2A (SMAP), binds to subunit PR65. |
| PC-27019 |
SDUY104
SHP2 inhibitor
|
SDUY104 is a potent, selective, allosteric SHP2 inhibitor with enzymatic IC50 of 0.14 uM. |
| PC-27018 |
SDUY038
SHP2 inhibitor
|
SDUY038 is a potent, selective, allosteric SHP2 inhibitor with high binding affinity (KD=0.29 uM), enzymatic IC50 of 1.2 uM. |
| PC-26846 |
SDUY127
SHP2 inhibitor
|
SDUY127 is a potent, bivalent, allosteric inhibitor of SHP2 (PTPN11) with IC50 of 16 nM, exhibits antiproliferative efficacy against MV4-11 cells through suppression of MAPK signaling. |
