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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-DDO-4279
DDO-4279

Chemical Structure : DDO-4279

CAS No.: 3121531-78-7

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DDO-4279 (DDO4279)

货号: PC-27292Not For Human Use, Lab Use Only.

DDO-4279 is a selective serine/threonine phosphatase PP5 degrader with DC50 of 6.9 uM, selectively degrades PP5 via the ubiquitin-proteasome pathway, thereby downregulating PP5 substrate proteins PPARγ and GR.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DDO-4279 is a selective serine/threonine phosphatase PP5 degrader with DC50 of 6.9 uM, selectively degrades PP5 via the ubiquitin-proteasome pathway, thereby downregulating PP5 substrate proteins PPARγ and GR.
DDO-4279 dose-dependently reduced body weight gain in ob/ob mice (outperforming the clinical drug semaglutide).
DDO-4279 ameliorated hepatomegaly and hepatic steatosis, and exhibited no renal toxicity.

物理化学性质&存储条件

分子量 335.78
分子式 C17H18ClNO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,2R,3S,4R)-3-(7-chloro-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid

参考文献

1. Mingxiao Gu, et al. RSC Med Chem. 2026 Jun 30. doi: 10.1039/d6md00191b.

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