PTPN22 inhibitor L-32

Chemical Structure : PTPN22 inhibitor L-32

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货号: PC-27250Not For Human Use, Lab Use Only.

PTPN22 inhibitor L-32 is a potent, selective PTPN22 inhibitor with IC50 of 0.49 uM and Ki of 0.28 uM, >14-fold selective over other PTPs.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PTPN22 inhibitor L-32 is a potent, selective PTPN22 inhibitor with IC50 of 0.49 uM and Ki of 0.28 uM, >14-fold selective over other PTPs.
L-32 competitively inhibits PTPN22 and makes putative interactions with multiple residues that are unique to PTPN22.
L-32 exhibits reduced inhibitory potency against the K136S, K136R, and K138A mutants (IC50=1.11-2.16 uM) relative to the wild-type enzyme.
L-32 (10 uM) increases LCK and ERK1/2 phosphorylation levels in a dose-dependent manner
L-32 efficiently enhances T cell signaling and activation, enhances α-CD28-mediated IL-2 expression and secretion from Jurkat T cells.
L-32 reduces MC38 tumor growth in MC38 tumor model in immune-competent C57BL/6J mice.

物理化学性质&存储条件

分子量	499.52
分子式	C28H25N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-(2-(4'-ethyl-3-hydroxy-[1,1'-biphenyl]-4-carboxamido)propanamido)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

参考文献

1. Lin J, et al. J Med Chem. 2026 Jul 2. doi: 10.1021/acs.jmedchem.5c03467.