| Cat. No. |
Product Name |
Information |
| PC-42129 |
SHP099 hydrochloride
SHP2 inhibitor
|
SHP099 hydrochloride is a potent, selective, allosteric and orally bioavailable protein tyrosine phosphatase SHP2 inhibitor with IC50 of 71 nM. |
| PC-42128 |
SHP099
SHP2 inhibitor
|
SHP099 (SHP-099) is a potent, selective, allosteric and orally bioavailable protein tyrosine phosphatase SHP2 inhibitor with IC50 of 71 nM. |
| PC-47481 |
Microcystin-LR
PP2A inhibitor
|
Microcystin-LR (MC-LR) is a potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM. |
| PC-45526 |
CPDA
SHIP2 inhibitor
|
CPDA is a potent SHIP2 inhibitor that enhances in vitro insulin signaling through the Akt pathway more efficiently than AS1949490, and ameliorates abnormal glucose metabolism in diabetic (db/db) mice. |
| PC-45470 |
LB-100
PP2A inhibitor
|
LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor. |
| PC-42304 |
NQ301
CD45 inhibitor
|
NQ301 (CD45 inhibitor 211, Compound 211) is a potent antithrombotic agent that inhibits thromboxane A2 receptor and synthase activity, also is a potent, selective inhibitor of CD45 tyrosine phosphatase with IC50 of 200 nM. |
| PC-42166 |
TPI-1
SHP-1 inhibitor
|
TPI-1 is a potent and selective, orally-active protein tyrosine phosphatases SHP-1 inhibitor with IC50 of 40 nM (0.01 ug/ml). |
| PC-42207 |
Stibogluconate sodium
PTPs inhibitor
|
Stibogluconate sodium (Sodium stibogluconate) is a multiple antimony compound that has leishmanicidal and potential antineoplastic activities, inhibits protein tyrosine phosphorylase SHP-1 (99% inhibtion at 10 ug/mL), SHP-2 and PTP1B, shows anticancer activity in synergy with IFNs. |
| PC-45510 |
LTV-1
PTPN22 inhibitor
|
LTV-1 is a highly potent, cell-permeable and reversible LYP (lymphoid tyrosine phosphatase, PTPN22) inhibitor with IC50 of 508 nM. |
| PC-42696 |
PTP1B-IN-1
PTP1B inhibitor
|
PTP1B-IN-1 is a 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for design of protein tyrosine phosphatase-1B (PTP1B) inhibitor, shows weak inhibition for PTP1B with IC50 of 1.6 mM. |
| PC-25611 |
PRLthiophenib
PRL-3 inhibitor
|
PRLthiophenib is a potent, selective inhibitor of phosphatase of regenerating liver 3 (PRL-3, PRL3) with IC50 of 7.8 uM, shows mucher weaker inhibitor for PRL-1 and -2 (IC50=31 uM and 15.8 uM), binds directly to PRL-3 with Kd of 23 uM. |
| PC-25608 |
Licoflavone A
PTP1B inhibitor
|
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B) with IC50 of 54.5 uM, also has anti-gastric cancer potency in vitro and in vivo, affects the proliferation, cycle, apoptosis, migration, invasion, and EMT by targeting VEGFR-2 and blocks the PI3K/AKT and MEK/ERK signaling pathways. |
