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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-AS1949490
AS1949490

Chemical Structure : AS1949490

CAS No.: 1203680-76-5

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AS1949490 (AS 1949490;AS-1949490)

货号: PC-70136Not For Human Use, Lab Use Only.

AS-1949490 (AS1949490) is a potent, selective SHIP2 inhibitor with IC50 of 0.34/0.62 uM for mouse/human SHIP2.

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5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥2880 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AS1949490 (AS 1949490) is a potent, selective SHIP2 inhibitor with IC50 of 0.34/0.62 uM for mouse/human SHIP2.
AS1949490 displays 30-fold selectivity over SHIP1, and other intracellular phosphatases.
AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake in L6 myotubes and suppresses gluconeogenesis in FAO hepatocytes.

物理化学性质&存储条件

分子量 371.88
分子式 C20H18ClNO2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]-2-thiophenecarboxamide

参考文献

1. Suwa A, et al. Br J Pharmacol. 2009 Oct;158(3):879-87.

2. Ichihara Y, et al. Eur J Med Chem. 2013 Apr;62:649-60.

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