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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-CS-11
CS-11

Chemical Structure : CS-11

CAS No.:

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CS-11 (CS11;CS 11)

货号: PC-70157Not For Human Use, Lab Use Only.

CS-11 is a novel small molecule inhibitor that inhibits PP2A and β-catenin interaction by selectively engaging PR55α binding site (Kd=45 pM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CS-11 is a novel small molecule inhibitor that inhibits PP2A and β-catenin interaction by selectively engaging PR55α binding site (Kd=45 pM).
    CS-11 diminishes the expression of active β-Catenin and its target proteins c-Myc and cyclin D1, promotes robust E-Cadherin upregulation on the cell surface and increases β-Catenin-E-Cadherin association.
    CS-11 shows activity both in vivo tumor growth and metastasis

    物理化学性质&存储条件

    分子量 441.53
    分子式 C27H27N3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((E)-2-hydroxy-3-isopropyl-5-((E)-3-oxo-3-(p-tolyl)prop-1-en-1-yl)benzylidene)-N-phenylhydrazine-1-carboxamide

    参考文献

    1. Maheshwari S, et al. Mol Cancer Ther. 2017 May 12. pii: molcanther.0584.2016.

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