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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-AQX 1125 acetate
AQX 1125 acetate

Chemical Structure : AQX 1125 acetate

CAS No.: 782487-29-0

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AQX 1125 acetate (AQX-1125 acetate;Rosiptor;AQX1125 acetate)

货号: PC-50005Not For Human Use, Lab Use Only.

AQX 1125 acetate (Rosiptor) is a sepecific, orally bioavailable SHIP1 activator with no effect on functional androgen, oestrogen, oestrogen-related receptor α, glucocorticoid, mineralocorticoid and progesterone receptor at 30 uM.

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    生物&药学活性

    AQX 1125 acetate (Rosiptor) is a sepecific, orally bioavailable SHIP1 activator with no effect on functional androgen, oestrogen, oestrogen-related receptor α, glucocorticoid, mineralocorticoid and progesterone receptor at 30 uM.
    AQX 1125 acetate (Rosiptor) inhibits the pAkt (S473) in MOLT-4 cells, and inhibits cytokine release in mixed splenocytes.
    AQX 1125 acetate (Rosiptor) significantly decreases β-hexosaminidase release in mouse BMMCs.
    AQX 1125 acetate (Rosiptor) inhibits chemotaxis in human mononuclear cells (EC50=0.26 uM).
    AQX 1125 acetate (Rosiptor) suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy.

    物理化学性质&存储条件

    分子量 381.557
    分子式 C22H39NO4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping Room temperature in continental US; may vary elsewhere
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexan-1-ol acetate

    参考文献

    1. Stenton GR, et al. Br J Pharmacol. 2013 Mar;168(6):1519-29.

    2. Stenton GR, et al. Br J Pharmacol. 2013 Mar;168(6):1506-18.

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