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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-SCB-4380
SCB-4380

Chemical Structure : SCB-4380

CAS No.: 915-67-3

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SCB-4380 (SCB 4380, SCB4380)

货号: PC-60421Not For Human Use, Lab Use Only.

SCB-4380 (SCB 4380, SCB4380) is the first potent, selective inhibitor for PTPRZ (protein tyrosine phosphatase receptor-type Z) with IC50 of 0.4 uM against human Z-ICR-catalyzed hydrolysis.

规格 价格 库存 数量
10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SCB-4380 (SCB 4380, SCB4380) is the first potent, selective inhibitor for PTPRZ (protein tyrosine phosphatase receptor-type Z) with IC50 of 0.4 uM against human Z-ICR-catalyzed hydrolysis.
SCB-4380 also strongly inhibits PTPRG (IC50=0.4 uM), and shows little inhibition on PTPRA, PTPRM, PTPRS, PTPRB, PTPN1 and PTPN6.
SCB-4380 inhibites PTPRZ activity in C6 glioblastoma cells, and suppresse cell migration and proliferation in vitro and tumor growth in a rat allograft model.

物理化学性质&存储条件

分子量 604.461
分子式 C20H11N2Na3O10S3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Trisodium 3-hydroxy-4-[(4-sulfonato-1-naphthyl)diazenyl]-2,7-naphthalenedisulfonate

参考文献

1. Fujikawa A, et al. Sci Rep. 2016 Feb 9;6:20473.

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