SMAP |Cas:1809427-19-7 Buy SMAP from ProbeChem, Global Biochemicals Supplier

Chemical Structure : DT-061

CAS No.: 1809427-19-7

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DT-061 (SMAP DT-061;NZ-8-061;DT061)

货号: PC-70158Not For Human Use, Lab Use Only.

SMAP (DT-061, NZ-8-061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4580	In stock
100 mg	￥9880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

SMAP (DT-061, NZ-8-061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth; acts by binding to the PP2A Aα scaffold subunit to drive conformational changes in PP2A.
SMAP (DT-061) inhibits the growth of KRAS-mutant lung cancers in mouse xenografts and transgenic models.

物理化学性质&存储条件

分子量	520.523
分子式	C25H23F3N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide, rel-

参考文献

1. Sangodkar J, et al. J Clin Invest. 2017 Jun 1;127(6):2081-2090.

2. Kauko O, et al. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.

DT-061 (SMAP DT-061;NZ-8-061;DT061)

生物&药学活性

物理化学性质&存储条件

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DT-061 (SMAP DT-061;NZ-8-061;DT061)

生物&药学活性

物理化学性质&存储条件

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