| Cat. No. |
Product Name |
Information |
| PC-36038 |
SHP394
SHP2 inhibitor
|
SHP394 (SHP-394, SHP 394) is a potent, selective, orally bioavailable inhibitor of SHP2 with IC50 of 23 nM, shows p-ERK inhibition with IC50 of 18 nM in cellular assays. |
| PC-35819 |
SHP2 inhibitor LY6
SHP2 inhibitor
|
SHP2 inhibitor LY6 (LY6) is a small molecule inhibitor that stabilizes the autoinhibited conformation of the oncogenic tyrosine phosphatase SHP2, inhibits SHP2 with IC50 of 9.8 uM, 7-fold selectivity over SHP1. |
| PC-35733 |
7-BIA
PTPRD inhibitor
|
7-BIA is a small molecule 7-butoxy illudalic acid analog that targets receptor-type protein tyrosine phosphatase D (PTPRD, IC50=1-3 uM) with some specificity. |
| PC-35687 |
PP1 inhibitor C31
PP1 inhibitor
|
PP1 inhibitor C31 is a 1E7-03 analog and protein phosphatase 1 (PP1) targeting small molecule with Kd of 1.88 uM, inhibits Ebola virus (EBOV) transcription and replication. |
| PC-35665 |
BI-0314
STEP activator
|
BI-0314 (BI0314) is an allosteric activator of protein tyrosine phosphatase non-receptor type 5 (PTPN5, STEP) with potency of 56% at 500 uM, displays no activity against hPTP1B and hTCPTP.. |
| PC-35654 |
AAL(S)
PP2A activator
|
AAL(S) is the chiral deoxy analog of the FDA approved drug FTY720, has been shown to inhibit proliferation and apoptosis in several cancer cell lines by activating protein phosphatase 2A (PP2A). |
| PC-35653 |
SH-BC-893
PP2A activator
|
SH-BC-893 is a water-soluble, orally bioavailable synthetic sphingolipid that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways in cancer cells, activates protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve. |
| PC-35559 |
JTT-551 sodium
PTP1B inhibitor
|
JTT-551 sodium (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR. |
| PC-35558 |
JTT-551
PTP1B inhibitor
|
JTT-551 (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR. |
| PC-35504 |
Guanabenz acetate
PPP1R15A inhibitor
|
Guanabenz acetate (Wytensin, WY-8678 acetate) is a small molecule that binds to PPP1R15A/GADD34, selectively disrupts the stress-induced dephosphorylation of eIF2α. |
| PC-35503 |
Raphin1
PPP1R15B inhibitor
|
Raphin1 (PPP1R15B inhibitor Raphin1) is a potent, selective, BBB-penetrant, orally bioavailable inhibitor of regulatory subunit of protein phosphatase 1, PPP1R15B, binds to the R15B-PP1c holophosphatase with Kd of 33 nM, 30-fold selective in binding R15B-PP1c over R15A-PP1c and did not bind to PP1c. |
| PC-35377 |
KY-226
PTP1B inhibitor
|
KY-226 (KY226) is a potent, allosteric, orally active inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 uM (human PTP1B), does not exhibit PPARγ agonist activity. |
