JMS-053 (KVX-053) | PTP4A inhibitor | Probechem Biochemicals

Chemical Structure : JMS-053

CAS No.: 1954650-11-3

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JMS-053 (JMS053, KVX-053)

货号: PC-73091Not For Human Use, Lab Use Only.

JMS-053 (KVX-053) is a potent, selective, reversible, and noncompetitive PTP4A inhibitor with IC50 of 50/53/18 nM for PTP4A1/PTP4A2/PTP4A3, respectively.

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5 mg	￥2580	In stock
10 mg	￥4280	In stock
50 mg	￥9980	In stock
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生物&药学活性

JMS-053 (KVX-053) is a potent, selective, reversible, and noncompetitive PTP4A inhibitor with IC50 of 50/53/18 nM for PTP4A1/PTP4A2/PTP4A3, respectively.
JMS-053 demonstrates high specificity against a panel of 25 other phosphatases and 50 kinases.
Pharmacological inhibition of PTP4A3 via JMS-053 normalizes VEGF- and LPS-induced decreases in transendothelial electric resistance (TEER).
JMS-053 inhibits OvCa cell proliferation (A2780 cell IC50=600 nM), spheroid viability, and migration.
JMS-053 inhibits RhoA activation in HeyA8 cells (IC50=0.6 uM) and has antitumor activity, inhibits drug-resistant OvCa tumor growth in vivo.

物理化学性质&存储条件

分子量	256.279
分子式	C13H8N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione

参考文献

1. McQueeney KE, et al. Oncotarget. 2017 Dec 30;9(9):8223-8240.

2. Salamoun JM, et al. Org Biomol Chem. 2016 Jul 6; 14(27):6398-402.

3. Lazo JS, et al. J Pharmacol Exp Ther. 2019 Dec;371(3):652-662.

4. Czub MP, et al. Mol Pharmacol. 2020 Dec;98(6):648-657.

JMS-053 (JMS053, KVX-053)

生物&药学活性

物理化学性质&存储条件

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JMS-053 (JMS053, KVX-053)

生物&药学活性

物理化学性质&存储条件

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