NHB1109 (Pentilludin) | PTPRD inhibitor | Probechem Biochemicals

Chemical Structure : NHB1109

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NHB1109 (NHB-1109, Pentilludin)

货号: PC-73348Not For Human Use, Lab Use Only.

NHB1109 (Pentilludin) is a potent, selective, orally active PTPRD phosphatase inhibitor with IC50 of 0.6 uM, displays selectivity over PTPRS, PTPRF, PTPRJ or PTPN1/PTP1B phosphatases.

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生物&药学活性

NHB1109 (Pentilludin) is a potent, selective, orally active PTPRD phosphatase inhibitor with IC50 of 0.6 uM, displays selectivity over PTPRS, PTPRF, PTPRJ or PTPN1/PTP1B phosphatases.
NHB1109 exhibited no substantial potency at other protein tyrosine phosphatases screened, no significant potency at any of the targets of clinically-useful drugs identified in EUROFINS screens.
NHB1109 (200 mg/kg) is well tolerated by mice.
NHB1109 is a good candidate to advance to in vivo studies in addiction paradigms and toward human use to reduce reward from addictive substances.

物理化学性质&存储条件

分子量	320.341
分子式	C17H20O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(cyclopentylmethoxy)-3-hydroxy-6-methoxy-1-oxoisochromane-5-carbaldehyde

参考文献

1. Ian M Henderson, et al. Biochem Pharmacol. 2022 Jan;195:114868.

NHB1109 (NHB-1109, Pentilludin)

生物&药学活性

物理化学性质&存储条件

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NHB1109 (NHB-1109, Pentilludin)

生物&药学活性

物理化学性质&存储条件

参考文献

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