DIPQUO

Chemical Structure : DIPQUO

CAS No.: 1269365-82-3

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货号: PC-72973Not For Human Use, Lab Use Only.

DIPQUO is a small molecule activator of the bone marker alkaline phosphatase (ALP) expression with EC50 of 6.27 uM, p38-β mediate DIQPUO-driven osteoblast differentiation effect.

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5 mg	￥2280	In stock
10 mg	￥3680	In stock
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100 mg		Get quote

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生物&药学活性

DIPQUO is a small molecule activator of the bone marker alkaline phosphatase (ALP) expression with EC50 of 6.27 uM, p38-β mediate DIQPUO-driven osteoblast differentiation effect.
DIPQUO markedly promotes osteoblast differentiation, including expression of Runx2, Osterix, and Osteocalcin.
Treatment of human mesenchymal stem cells with DIPQUO results in osteogenic differentiation including a significant increase in calcium matrix deposition.
DIPQUO stimulates ossification of emerging vertebral primordia in developing zebrafish larvae, and increases caudal fin osteogenic differentiation during adult zebrafish fin regeneration.
DIPQUO functions mechanistically through activation of p38 MAPK signaling, selectively activated p38 MAPK signaling while it suppressed the p54 isoform of the c-terminal Jun kinase family.

物理化学性质&存储条件

分子量	315.376
分子式	C20H17N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6,8-dimethyl-3-(4-phenyl-1H-imidazol-5-yl)quinolin-2(1H)-one

参考文献

1. Brandoch Cook, et al. Cell Chem Biol. 2019 Jul 18;26(7):926-935.e6.

2. Cook B, et al. J Biol Chem. 2021 Jan-Jun;296:100696.

DIPQUO

生物&药学活性

物理化学性质&存储条件

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DIPQUO

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