MLS000544460 | EYA2 inhibitor | Probechem Biochemicals

Chemical Structure : MLS000544460

CAS No.: 352336-36-8

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MLS000544460 (EYA2i)

货号: PC-72461Not For Human Use, Lab Use Only.

MLS000544460 (EYA2i) is a specific, allosteric inhibitor of Eya2 phosphatase with IC50 of 4.1 uM, KD of 2.0 uM, does not bind Eya3 ED, Eya1 and Eya4 ED.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MLS000544460 (EYA2i) is a specific, allosteric inhibitor of Eya2 phosphatase with IC50 of 4.1 uM, KD of 2.0 uM, does not bind Eya3 ED, Eya1 and Eya4 ED.
MLS000544460 inhibits Eya2-mediated cell migration.
MLS000544460 decreased mesenchymal phenotypes and enhanced cancer cell immunogenicity, resulting in attenuated tumor growth and metastasis.
MLS000544460 treatment increased infiltration of cytotoxic T and NK cells, and enhanced anti-PD-1 therapy response in mouse tumor models.
Inhibition of the EYA2 Tyr phosphatase activity via MLS000544460, mimicked EYA2 loss in glioblastoma stem cells (GSCs) in vitro and extended the survival of tumor-bearing mice.

物理化学性质&存储条件

分子量	341.36
分子式	C17H12FN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Fluorobenzoic acid 2-[[5-(2-pyridinylthio)-2-furanyl]methylene]hydrazide

参考文献

1. Zhang G, et al. J Exp Med. 2021 Nov 1;218(11):e20202669.

2. Jia Z Shen, et al. Mol Cell. 2022 Feb 11;S1097-2765(22)00087-9.

3. Krueger AB, et al. J Biol Chem. 2014 Jun 6;289(23):16349-61.

MLS000544460 (EYA2i)

生物&药学活性

物理化学性质&存储条件

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MLS000544460 (EYA2i)

生物&药学活性

物理化学性质&存储条件

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