DS-1211 | TNAP inhibitor | Probechem Biochemicals

Chemical Structure : DS-1211

加入收藏

DS-1211 (DS1211)

货号: PC-49299Not For Human Use, Lab Use Only.

DS-1211 (DS1211) is a potent, selecitve inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with IC50 of 3.4 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DS-1211 (DS1211) is a potent, selecitve inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with IC50 of 3.4 nM.
DS-1211 displays >400-fold selectivity over intestinal alkaline phosphatase (IAP) and placental alkaline phosphatase (PLAP), also shows no significant response(≥50% inhibition) on a total of 88 receptors, channels, transporters, and enzymes.
DS-1211 exhibits TNAP selectivity and potent inhibition of TNAP across species.
DS-1211 inhibits ALP activity through an uncompetitive mode of action.
DS-1211 effetively inhibits mouse, monkey, and human plasma alkaline phosphatase with IC50 of 13.3, 36.3 and 28.3 nM, respectively.
Single oral administration of DS-1211 showed linear pharmacokinetics, with dose-dependent inhibition of ALP activity, and increases in plasma PPi and PLP in vivo.

物理化学性质&存储条件

分子量	367.351
分子式	C15H14FN3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-fluoro-2-methoxy-N-(5-oxo-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-7-yl)benzenesulfonamide

参考文献

1. Soma K, et al. J Bone Miner Res. 2022 Aug 23. doi:10.1002/jbmr.4680.

DS-1211 (DS1211)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

DS-1211 (DS1211)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.