| Cat. No. |
Product Name |
Information |
| PC-24357 |
Dyr726
PI3Kα inhibitor
|
Dyr726 is a potent, selective and brain-penetrant inhibitor of PI3Kα with IC50 of 3.6 nM, >1,000-fold selective against the β and γ-PI3K isoforms. |
| PC-24150 |
F0608-0019
PI3Kα inhibitor
|
F0608-0019 is a highly potent and selective PI3Kα inhibitor with IC50 of 0.47 uM. |
| PC-23844 |
PF-04691502
PI3K/mTOR inhibitor
|
PF-04691502 is a potent, selective, ATP-competitive PI3K/mTOR dual inhibitor with Ki of 1.8/1.2 nM (human/mouse PI3Kα), 2.1/1.6/1.9 nM (PI3Kβ/δ/γ) and 16 nM (human mTOR). |
| PC-23786 |
VVD-844
p110α RBD inhibitor
|
VVD-844 is a specific, covalent inhibitor of RAS binding domain of PI3Kα (p110α RBD), disrupts the RAS-p110α interaction, binds covalently to Cys242 in p110α RBD and blocks the ability of RAS to activate PI3K activity. |
| PC-23785 |
VVD-699
p110α RBD inhibitor
|
VVD-699 is a specific, covalent inhibitor of RAS binding domain of PI3Kα (p110α RBD), disrupts the RAS-p110α interaction, binds covalently to Cys242 in p110α RBD and blocks the ability of RAS to activate PI3K activity. |
| PC-23729 |
JN-KI3
PI3Kγ inhibitor
|
JN-KI3 is a potent, selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 3.87 uM, with no actiivity against PI3Kα, PI3Kβ and PI3Kδ (IC50>20 uM). |
| PC-23245 |
Menadione sodium bisulfite
Vps34 inhibitor
|
Menadione sodium bisulfite (MSB) is a water-soluble form of vitamin K precursor menadione, suppresses prostate cancer growth by targeting the kinase VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3). |
| PC-23119 |
AS041164
PI3Kγ inhibitor
|
AS041164 is a potent, selective and orally bioavailable PI3Kγ inhibitor with IC50 of 70 nM, blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation. |
| PC-23007 |
PITCOIN1
PI3KC2α inhibitor
|
PITCOIN1 is a potent, highly selective inhibitor of class II alpha PI3K (PI3K-C2α) with IC50 of 100 nM, with no activity against class I and III PI3Ks. |
| PC-23006 |
PI-701
PI3KC2β inhibitor
|
PI-701 (YM185453) is a selective inhibitor of class II PI3KC2β isoform with IC50 of 528 nM, does not display activity toward PI3K class I isoforms. |
| PC-23005 |
PI3K-C2γ inhibitor 26
PI3K-C2γ inhibitor
|
PI3K-C2γ inhibitor 26 is a potent, isoform-selective inhibitor of PI3K-C2γ with IC50 of 340 nM, with no activity against class I and III PI3Ks or a panel of 60 other protein kinases. |
| PC-23004 |
MIPS-21335
PI3KC2α inhibitor
|
MIPS-19416 is a potent selective inhibitor of class II alpha PI3K (PI3K-C2α) with IC50 of 7 nM, six-fold selective over PI3K-C2β, 20-fold over PI3K-p110α. |
