Dactolisib |CAS:915019-65-7 Probechem Biochemicals

Chemical Structure : Dactolisib

CAS No.: 915019-65-7

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Dactolisib (NVP-BEZ235;BEZ-235)

货号: PC-45837Not For Human Use, Lab Use Only.

Dactolisib (NVP-BEZ235) is a potent, dual ATP-competitive pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively.

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100 mg	￥1480	In stock
200 mg	￥2480	In stock
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生物&药学活性

Dactolisib (NVP-BEZ235) is a potent, dual ATP-competitive pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively.
Dactolisib (NVP-BEZ235) effectively and specifically blocks the dysfunctional activation of the PI3K pathway, inducing G(1) arrest; demonstrates antitumor activity in in vivo models of human cancer.

物理化学性质&存储条件

分子量	469.5365
分子式	C30H23N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 8.75 mg/mL
Chemical Name/SMILES	Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-.alpha.,.alpha.-dimethyl-

参考文献

1. Maira SM, et al. Mol Cancer Ther. 2008 Jul;7(7):1851-63.

2. Serra V, et al. Cancer Res. 2008 Oct 1;68(19):8022-30.

3. Schnell CR, et al. Cancer Res. 2008 Aug 15;68(16):6598-607.

Dactolisib (NVP-BEZ235;BEZ-235)

生物&药学活性

物理化学性质&存储条件

参考文献

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Dactolisib (NVP-BEZ235;BEZ-235)

生物&药学活性

物理化学性质&存储条件

参考文献

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