| Cat. No. |
Product Name |
Information |
| PC-42133 |
PF-04979064
PI3K/mTOR inhibitor
|
PF-04979064 is a highly potent and selective, dual PI3K/mTOR inhibitor with Ki of 0.13, 0.111, 0.122 and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ and mTOR, respectively. |
| PC-42310 |
LY294002
PI3K inhibitor
|
LY294002 is a classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively. |
| PC-28557 |
PI3Kα H1047R inhibitor compound 34
PI3Kα H1047R inhibitor
|
PI3Kα H1047R inhibitor compound 34 is a potent and mutant-selective of mutant PI3Kα H1047R. |
| PC-27224 |
PX-866
PI3K inhibitor
|
Sonolisib (PX-866) is a Wortmannin analogue and an oral, irreversible, and pan-isoform PI3K inhibitor with IC50 of 0.1 nM, 1.0 nM and 2.9 nM for p110α, p120γ and p110δ. |
| PC-26400 |
LASSBio-2337
PI3K/mTOR inhibitor
|
LASSBio-2337 is a potent, dual pan-PI3K/mTOR inhibitor with IC50 of 0.3, 4.2, 0.6, 7.5 and 5.8 uM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR respectively, shows cytotoxic effects in leukemia cell lines with CC50 of 4.37-9.44 uM. |
| PC-25553 |
D-106669
PI3Kα inhibitor
|
D-106669 (Compound 150) is a potent, selective inhibitor of PI3Kα with IC50 of 129 nM. |
| PC-25286 |
DW09849
PI3Kα inhibitor
|
DW09849 is a highly potent, selective PI3Kα inhibitor, inhibits proliferation of rhabdomyosarcoma RH30 cells. |
| PC-25282 |
CNX-1351
PI3Kα inhibitor
|
CNX-1351 (CNX1351) is a potent, isoform-selective and covalent inhibitor of PI3Kα with IC50 of 6.8 nM, covalently modifies PI3Kα on cysteine 862 (C862). |
| PC-25225 |
D223
GLUT4 activator
|
D927 (DS11252927) is a small molecule glue and GLUT4 activator that facilitate RAS binding to PI3Kα, promotes glucose uptake in the absence of insulin, binds directly to p110α with dissociation constant (KD) of 0.76 uM. |
| PC-25224 |
D927
GLUT4 activator
|
D927 (DS11252927) is a small molecule glue and GLUT4 activator that facilitate RAS binding to PI3Kα, promotes glucose uptake in the absence of insulin, binds directly to p110α with dissociation constant (KD) of 5.6 uM. |
| PC-25114 |
MIPS-19417
PI3KC2β inhibitor
|
MIPS-19417 is a potent, selective PI3KC2β inhibitor with IC50 of 278 nM, does not inhibit PI3KC2α (IC50>10 uM). |
| PC-24779 |
CKD712
PI3K activator
|
(S)-YS-49 (YS49) is a small molecule PI3K activator and positive inotropic isoquinoline compound. |
