| Cat. No. |
Product Name |
Information |
| PC-25224 |
D927
GLUT4 activator
|
D927 (DS11252927) is a small molecule glue and GLUT4 activator that facilitate RAS binding to PI3Kα, promotes glucose uptake in the absence of insulin, binds directly to p110α with dissociation constant (KD) of 5.6 uM. |
| PC-25114 |
MIPS-19417
PI3KC2β inhibitor
|
MIPS-19417 is a potent, selective PI3KC2β inhibitor with IC50 of 278 nM, does not inhibit PI3KC2α (IC50>10 uM). |
| PC-24779 |
CKD712
PI3K activator
|
(S)-YS-49 (YS49) is a small molecule PI3K activator and positive inotropic isoquinoline compound. |
| PC-24778 |
YS-49
PI3K activator
|
YS-49 (YS49) is a small molecule PI3K activator and positive inotropic isoquinoline compound. |
| PC-24602 |
Deguelin
FBXO22 inhibitor
|
Deguelin is a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis, also is a potential inhibitor of FBXO22. |
| PC-24357 |
Dyr726
PI3Kα inhibitor
|
Dyr726 is a potent, selective and brain-penetrant inhibitor of PI3Kα with IC50 of 3.6 nM, >1,000-fold selective against the β and γ-PI3K isoforms. |
| PC-24150 |
F0608-0019
PI3Kα inhibitor
|
F0608-0019 is a highly potent and selective PI3Kα inhibitor with IC50 of 0.47 uM. |
| PC-23844 |
PF-04691502
PI3K/mTOR inhibitor
|
PF-04691502 is a potent, selective, ATP-competitive PI3K/mTOR dual inhibitor with Ki of 1.8/1.2 nM (human/mouse PI3Kα), 2.1/1.6/1.9 nM (PI3Kβ/δ/γ) and 16 nM (human mTOR). |
| PC-23786 |
VVD-844
p110α RBD inhibitor
|
VVD-844 is a specific, covalent inhibitor of RAS binding domain of PI3Kα (p110α RBD), disrupts the RAS-p110α interaction, binds covalently to Cys242 in p110α RBD and blocks the ability of RAS to activate PI3K activity. |
| PC-23785 |
VVD-699
p110α RBD inhibitor
|
VVD-699 is a specific, covalent inhibitor of RAS binding domain of PI3Kα (p110α RBD), disrupts the RAS-p110α interaction, binds covalently to Cys242 in p110α RBD and blocks the ability of RAS to activate PI3K activity. |
| PC-23729 |
JN-KI3
PI3Kγ inhibitor
|
JN-KI3 is a potent, selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 3.87 uM, with no actiivity against PI3Kα, PI3Kβ and PI3Kδ (IC50>20 uM). |
| PC-23245 |
Menadione sodium bisulfite
Vps34 inhibitor
|
Menadione sodium bisulfite (MSB) is a water-soluble form of vitamin K precursor menadione, suppresses prostate cancer growth by targeting the kinase VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3). |
