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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-VVD-844
VVD-844

Chemical Structure : VVD-844

CAS No.:

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VVD-844 (VVD-172844)

货号: PC-23786Not For Human Use, Lab Use Only.

VVD-844 is a specific, covalent inhibitor of RAS binding domain of PI3Kα (p110α RBD), disrupts the RAS-p110α interaction, binds covalently to Cys242 in p110α RBD and blocks the ability of RAS to activate PI3K activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VVD-844 is a specific, covalent inhibitor of RAS binding domain of PI3Kα (p110α RBD), disrupts the RAS-p110α interaction, binds covalently to Cys242 in p110α RBD and blocks the ability of RAS to activate PI3K activity.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Klebba JE, et al. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001.

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