CKD712 | PI3K activator | Probechem Biochemicals

Chemical Structure : CKD712

CAS No.: 626252-75-3

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CKD712 ((S)-YS-49, CKD-712)

货号: PC-24779Not For Human Use, Lab Use Only.

(S)-YS-49 (YS49) is a small molecule PI3K activator and positive inotropic isoquinoline compound.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

(S)-YS-49 (YS49) is a small molecule PI3K activator and positive inotropic isoquinoline compound.
(S)-YS-49 suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.
(S)-YS-49 inhibits apoptosis in myocardial ischemia and reperfusion (I/R) injury in vivo via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and by reducing inflammation during I/R.

物理化学性质&存储条件

分子量	305.38
分子式	C20H19NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S)-1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol

参考文献

1. Jin YC, et al. J Pharmacol Exp Ther. 2009 Aug;330(2):440-8.

CKD712 ((S)-YS-49, CKD-712)

生物&药学活性

物理化学性质&存储条件

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CKD712 ((S)-YS-49, CKD-712)

生物&药学活性

物理化学性质&存储条件

参考文献

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