SF2523 |CAS:1174428-47-7 Probechem Biochemicals

Chemical Structure : SF2523

CAS No.: 1174428-47-7

加入收藏

SF2523 (SF-2523;SF 2523)

货号: PC-42326Not For Human Use, Lab Use Only.

SF2523 is a potent, dual inhibitor of PI3K and BRD4 with IC50 of 241, 34, 158 nM for BRD4 (BD1), PI3Kα and PI3Kγ, respectively.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SF2523 is a potent, dual inhibitor of PI3K and BRD4 with IC50 of 241, 34, 158 nM for BRD4 (BD1), PI3Kα and PI3Kγ, respectively.
SF2523 interacts robustly with the full-length BRD4 (Kd=140 nM) and BRD4(BD1) (Kd=150 nM), binds more weakly BRD4(BD2) (Kd = 710 nM).
SF2523 blocks MYC expression and activation, promotes MYC degradation, and markedly inhibits cancer cell growth and metastasis both in vitro and in vivo.

物理化学性质&存储条件

分子量	371.40698
分子式	C19H17NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	7H-Thieno[3,2-b]pyran-7-one, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(4-morpholinyl)-

参考文献

1. Andrews FH, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1072-E1080.

2. Carlino L, et al. J Med Chem. 2016 Oct 27;59(20):9305-9320.

3. Shen G, et al. Biochem Biophys Res Commun. 2017 Nov 10. pii: S0006-291X(17)32240-4.

SF2523 (SF-2523;SF 2523)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SF2523 (SF-2523;SF 2523)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.