PKI-402 |CAS:1173204-81-3 Probechem Biochemicals

Chemical Structure : PKI-402

CAS No.: 1173204-81-3

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PKI-402 (PKI 402;PKI402)

货号: PC-42695Not For Human Use, Lab Use Only.

PKI-402 is a potent dual PI3K/mTOR inhibitor with IC50 of 1/7/16/14/1.7 nM for PI3Kα/β/γ/δ/mTOR respectively.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
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100 mg		Get quote

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生物&药学活性

PKI-402 is a potent dual PI3K/mTOR inhibitor with IC50 of 1/7/16/14/1.7 nM for PI3Kα/β/γ/δ/mTOR respectively.
PKI-402 shows excellent suppression of Akt T308 phosphorylation (IC50=5 nM), and excellent inhibition of cell proliferation in several human cancer cell lines.
PKI-402 shows excellent in vivo efficacy in various human cancer xenografts, good physical properties and PK parameters.

物理化学性质&存储条件

分子量	570.6454
分子式	C29H34N10O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: < 1 mg/mL
Chemical Name/SMILES	Urea, N-[4-[3-ethyl-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-

参考文献

1. Dehnhardt CM, et al. J Med Chem. 2010 Jan 28;53(2):798-810.

2. Mallon R, et al. Mol Cancer Ther. 2010 Apr;9(4):976-84.

PKI-402 (PKI 402;PKI402)

生物&药学活性

物理化学性质&存储条件

参考文献

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PKI-402 (PKI 402;PKI402)

生物&药学活性

物理化学性质&存储条件

参考文献

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