IC-87114 |CAS:371242-69-2 Probechem Biochemicals

Chemical Structure : IC-87114

CAS No.: 371242-69-2

加入收藏

IC-87114 (IC87114;IC 87114)

货号: PC-42315Not For Human Use, Lab Use Only.

IC-87114 (IC87114) is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM.

规格	价格	库存
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4980	In stock
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IC-87114 (IC87114) is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM.
IC-87114 displays 58-fold selectivity over PI3Kγ, and >100-fold over PI3Kα and PI3Kβ.
IC-87114 inhibits polarized morphology of neutrophils, fMLP-stimulated PIP3 production and chemotaxis.
IC-87114 inhibits constitutive phosphorylation of Akt/PKB and suppresses AML cell proliferation.
IC-87114 reduces vascular permeability in a murine model of asthma.

物理化学性质&存储条件

分子量	397.4326
分子式	C22H19N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4(3H)-Quinazolinone, 2-[(6-amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-

参考文献

1. Sadhu C, et al. J Immunol. 2003 Mar 1;170(5):2647-54.

2. Billottet C, et al. Oncogene. 2006 Oct 26;25(50):6648-59.

3. Puri KD, et al. Blood. 2004 May 1;103(9):3448-56.

4. Lee KS, et al. J Allergy Clin Immunol. 2006 Aug;118(2):403-9.

IC-87114 (IC87114;IC 87114)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

IC-87114 (IC87114;IC 87114)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.