Leniolisib (CDZ173) | PI3Kδ inhibitor | Probechem Biochemicals

Chemical Structure : Leniolisib

CAS No.: 1354690-24-6

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Leniolisib (CDZ-173, CDZ173)

货号: PC-45394Not For Human Use, Lab Use Only.

Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 11 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
50 mg	￥4580	In stock
100 mg	￥7880	In stock
250 mg		Get quote

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生物&药学活性

Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 11 nM.
Leniolisib (CDZ173) displays >20-fold, 40-fold, and 200-fold selectivity over PI3Kα, PI3Kβ, and PI3Kγ, respectively.
Leniolisib (CDZ173) shows 30-fold cellular selectivity over PI3Kα; inhibits a large spectrum of immune cell functions, as demonstrated in B and T cells, neutrophils, monocytes, basophils, plasmocytoid dendritic cells, and mast cells in vitro.
Leniolisib (CDZ173) potently inhibits antigen-specific antibody production and reduces disease symptoms in a rat collagen-induced arthritis model.

物理化学性质&存储条件

分子量	450.4574
分子式	C21H25F3N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥150 mg/mL
Chemical Name/SMILES	1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]-

参考文献

1. Klemens Hoegenauer, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00293

2. Rao VK, et al. Blood. 2017 Nov 23;130(21):2307-2316.

Leniolisib (CDZ-173, CDZ173)

生物&药学活性

物理化学性质&存储条件

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Leniolisib (CDZ-173, CDZ173)

生物&药学活性

物理化学性质&存储条件

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