Seletalisib |CAS:1362850-20-1 Probechem Biochemicals

Chemical Structure : Seletalisib

CAS No.: 1362850-20-1

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Seletalisib (UCB-5857, UCB5857)

货号: PC-45071Not For Human Use, Lab Use Only.

Seletalisib (UCB-5857) is a potent, ATP-competitive, and selective PI3Kδ inhibitor with IC50 of 12 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

Seletalisib (UCB-5857) is a potent, ATP-competitive, and selective PI3Kδ inhibitor with IC50 of 12 nM.
Seletalisib (UCB-5857) shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (204-303 fold).
Seletalisib (UCB-5857) blocks AKT phosphorylation following activation of the B-cell receptor in a B-cell line.
Seletalisib (UCB-5857) blocks human T-cell production of several cytokines from activated T-cells, and inhibits B-cell proliferation and cytokine release.
Seletalisib (UCB-5857) dose-dependently inhibits anti-CD3-antibody-induced interleukin 2 release in mice.

物理化学性质&存储条件

分子量	482.8451
分子式	C23H14ClF3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥83.3 mg/mL
Chemical Name/SMILES	Pyrido[3,2-d]pyrimidin-4-amine, N-[(1R)-1-[8-chloro-2-(1-oxido-3-pyridinyl)-3-quinolinyl]-2,2,2-trifluoroethyl]-

参考文献

1. Allen RA, et al. J Pharmacol Exp Ther. 2017 Jun;361(3):429-440.

Seletalisib (UCB-5857, UCB5857)

生物&药学活性

物理化学性质&存储条件

参考文献

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Seletalisib (UCB-5857, UCB5857)

生物&药学活性

物理化学性质&存储条件

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