| Cat. No. |
Product Name |
Information |
| PC-49117 |
Ansornitinib
Fibrokinase inhibitor
|
Ansornitinib (ANG-3070, ANG3070) is an oral fibrokinase inhibitor inhibitor of PDGFR and VEGFR/KDR with high binding affinity, also targets Discoidin Domain Receptors 1 and 2 (DDR1 and DDR2), tyrosine kinase receptors linked to the development of fibrosis in the kidneys and lungs. |
| PC-47008 |
Seralutinib
PDGFR inhibitor
|
Seralutinib (GB002) is a potent, selective kinase inhibitor that targets PDGFRα/β, CSF1R, and c-KIT, and increases BMPR2, shows potential for treatment of pulmonary arterial hypertension. |
| PC-42865 |
CP-673451
PDGFR inhibitor
|
CP-673451 is a potent, selective, orally acitve PDGFR inhibitor with IC50 of 1 and 10 nM for PDGFR-α and PDGFR-β, respectively. |
| PC-62019 |
Megakaryopoiesis inducer MK1
Megakaryopoiesis inducer, PDGFR inducer
|
MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation. |
| PC-61280 |
AG-1295
PDGFR inhibitor
|
A quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1 uM. |
| PC-42725 |
N-Desethyl Sunitinib
VEGFR/PDGFR inhibitor
|
N-Desethyl Sunitinib is the active metabolite of sunitinib, which is an oral, small-molecule, multi-targeted RTKs inhibitor, sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor. |
| PC-42630 |
TSU-68
|
TSU-68 (Orantinib, SU6668) is a small-molecule, ATP-competitive inhibitor of angiogenic related RTKs KDR, PDGFRβ, FGFR1. |
| PC-45430 |
AZD2932
PDGFRβ inhibitor
|
AZD2932 is a potent multikinase inhibitor that inhibits PDGFRβ, VEGFR-2, Flt-3 and CSF-1R with IC50 of 4, 8, 100, and 7 nM, respectively. |
| PC-42555 |
PP121
PDGFR inhibitor
|
A multitargeted, dual tyrosine and PI3K kinase inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2, 8, 10, 12, 14 and 18 nM. |
| PC-42490 |
Sunitinib
VEGFR2/PDGFR inhibitor
|
A multi-targeted RTK inhibitor that targets VEGFR2 (Flk-1) and PDGFRβ with Ki of 8 nM and 9 nM respectively. |
| PC-22702 |
WQ-C-401
PDGFR inhibitor
|
WQ-C-401 is a highly potent, selective PDGFR inhibitor, inhibits PDGFRα/β autophosphorylation in PDGFRα/β wt-transformed BaF3 isogenic cells with IC50 of 3/11 nM respectively. |
| PC-62329 |
SU 16f
|
SU 16f is a potent and selective PDGFRβ inhibitor with IC50 of 10 nM, displays >14-fold, >229-fold and >10,000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. |
