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首页-小分子抑制剂&激动剂-Tyrosine Kinase-PDGFR-AG-1295
AG-1295

Chemical Structure : AG-1295

CAS No.: 71897-07-9

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AG-1295 (NSC 380341, Tyrphostin AG1295)

货号: PC-61280Not For Human Use, Lab Use Only.

A quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1 uM.

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10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AG-1295 (Tyrphostin AG1295) is a quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1 uM.
AG-1295 inhibits PDGF-stimulated DNA synthesis with IC50 of 2.5 uM without affecting activity of EGFR.
AG-1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine.

物理化学性质&存储条件

分子量 234.3
分子式 C16H14N2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6,7-dimethyl-2-phenyl-quinoxaline

参考文献

1. Kovalenko M, et al. Cancer Res. 1994 Dec 1;54(23):6106-14.

2. Banai S, et al. Circulation. 1998 May 19;97(19):1960-9.

3. Iwamoto H, et al. J Lab Clin Med. 2000 May;135(5):406-12.

4. Karck M, et al. Transplantation. 2002 Nov 15;74(9):1335-41.

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