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首页-小分子抑制剂&激动剂-Tyrosine Kinase-PDGFR-Seralutinib
Seralutinib

Chemical Structure : Seralutinib

CAS No.: 1619931-27-9

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Seralutinib (GB002, PK-10571)

货号: PC-47008Not For Human Use, Lab Use Only.

Seralutinib (GB002) is a potent, selective kinase inhibitor that targets PDGFRα/β, CSF1R, and c-KIT, and increases BMPR2, shows potential for treatment of pulmonary arterial hypertension.

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10 mg ￥1480 In stock
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50 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Seralutinib (GB002) is a potent, selective kinase inhibitor that targets PDGFRα/β, CSF1R, and c-KIT, and increases BMPR2, shows potential for treatment of pulmonary arterial hypertension.

物理化学性质&存储条件

分子量 469.545
分子式 C27H27N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)pyrazin-2-yl]amino]ethyl]phenyl]-5-methylpyridine-3-carboxamide

参考文献

1. Frantz RP, et al. Pulm Circ. 2021 Nov 11;11(4):20458940211057071.

2. Galkin A, et al. Eur Respir J. 2022 Jun 9:2102356.

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