WQ-C-401

Chemical Structure : WQ-C-401

加入收藏

货号: PC-22702Not For Human Use, Lab Use Only.

WQ-C-401 is a highly potent, selective PDGFR inhibitor, inhibits PDGFRα/β autophosphorylation in PDGFRα/β wt-transformed BaF3 isogenic cells with IC50 of 3/11 nM respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

WQ-C-401 is a highly potent, selective PDGFR inhibitor, inhibits PDGFRα/β autophosphorylation in PDGFRα/β wt-transformed BaF3 isogenic cells with IC50 of 3/11 nM respectively.
WQ-C-401 exhibits good selectivity for PDGFR (S score (1) = (0.01) at a concentration of 1 μM.
WQ-C-401 also exhibits binding affinity for the kinases cKIT and CSF1R, but only moderately inhibits CSF1R (GI50 = 0.13 μM) and does not affect tel-cKIT-BaF3 cells (GI50 > 10 μM).
WQ-C-401 (1 uM) decreased PDGF-BB-induced migration in a concentration-dependent manner in human PASMCs.
WQ-C-401 (25, 50, 100 mg/kg/d) significantly attenuated MCT-induced pulmonary artery hypertrophy, suppressed MCT-induced cell hyperproliferation and CD68+ macrophage infiltration around the pulmonary artery.

物理化学性质&存储条件

分子量	418.50
分子式	C24H26N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-methyl-3-((1-(1-methyl-1H-imidazole-4-carbonyl)piperidin-4-yl)oxy)phenyl)benzamide

参考文献

1. Huang W, et al. xp Cell Res. 2024 Jul 10:114154.

WQ-C-401

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

WQ-C-401

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.