Megakaryopoiesis inducer MK1 |CAS:1026307-65-2 Probechem Biochemicals

Chemical Structure : Megakaryopoiesis inducer MK1

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Megakaryopoiesis inducer MK1 (MK1)

货号: PC-62019Not For Human Use, Lab Use Only.

MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation.

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生物&药学活性

MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation.
MK1 is a PDGFR inhibitor that inhibits PDGF-CC-mediated PDGFR phosphorylation in U138-malignant glioma cells.
MK1 also inhibits the PDGF-CC-induced phosphorylation of PLCγ1, a major downstream target of PDGFR.

物理化学性质&存储条件

分子量	573.58
分子式	C30H26F3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(7-((2,6-dimethylpyridin-3-yl)amino)-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)-N-(3-(trifluoromethyl)phenyl)-4-vinylbenzamide

参考文献

1. Boitano AE, et al. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14019-23.

Megakaryopoiesis inducer MK1 (MK1)

生物&药学活性

物理化学性质&存储条件

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Megakaryopoiesis inducer MK1 (MK1)

生物&药学活性

物理化学性质&存储条件

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