CP-673451 |CAS:343787-29-1 Probechem Biochemicals

Chemical Structure : CP-673451

CAS No.: 343787-29-1

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CP-673451 (CP 673451;CP673451)

货号: PC-42865Not For Human Use, Lab Use Only.

CP-673451 is a potent, selective, orally acitve PDGFR inhibitor with IC50 of 1 and 10 nM for PDGFR-α and PDGFR-β, respectively.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2880	In stock
100 mg		Get quote

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生物&药学活性

CP-673451 is a potent, selective, orally acitve PDGFR inhibitor with IC50 of 1 and 10 nM for PDGFR-α and PDGFR-β, respectively.
CP-673451 inhibits PDGFR-β autophosphorylation with IC50 of 1 nM in cell-based assyas, displays >450-fold selectivity over other angiogenic receptors, including VEGFR-1, VEGFR-2, TIE-2, and FGFR-2.
CP-673451 inhibits PDGFR phosphorylation in tumor xenografts and inhibits multiple types tumor growth in vivo.
CP-673451 also robustly inhibits centrosome clusterin, induces mitotic spindle multipolarity by activation of the actin-severing protein cofilin in cancer cells.

物理化学性质&存储条件

分子量	417.5035
分子式	C24H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Piperidinamine, 1-[2-[5-(2-methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-

参考文献

1. Roberts WG, et al. Cancer Res. 2005 Feb 1;65(3):957-66.

2. Ehnman M, et al. Cancer Res. 2013 Apr 1;73(7):2139-49.

3. Chintalgattu V, et al. Sci Transl Med. 2013 May 29;5(187):187ra69.

4. Konotop G, et al. Cancer Res. 2016 Nov 15;76(22):6690-6700.

CP-673451 (CP 673451;CP673451)

生物&药学活性

物理化学性质&存储条件

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CP-673451 (CP 673451;CP673451)

生物&药学活性

物理化学性质&存储条件

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