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首页-小分子抑制剂&激动剂-Tyrosine Kinase-PDGFR-PP121
PP121

Chemical Structure : PP121

CAS No.: 1092788-83-4

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PP121 (PP 121;PP-121)

货号: PC-42555Not For Human Use, Lab Use Only.

A multitargeted, dual tyrosine and PI3K kinase inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2, 8, 10, 12, 14 and 18 nM.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PP121 is a multitargeted, dual tyrosine and PI3K kinase inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2, 8, 10, 12, 14 and 18 nM.
PP121 also inhibits Ret, VEGFR-2, 110α/mTOR, potently inhibits both tyrosine kinases and PI3Ks but not serine-threonine kinases.

物理化学性质&存储条件

分子量 319.3638
分子式 C17H17N7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-

参考文献

1. Apsel B, et al. Nat Chem Biol. 2008 Nov;4(11):691-9.

2. Che HY, et al. Tumour Biol. 2014 Sep;35(9):8659-64.

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