Toceranib (PHA 291639, SU11654) | Multikinase inhibitor

Chemical Structure : Toceranib

CAS No.: 356068-94-5

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Toceranib (PHA 291639, SU11654, SU-11654, PHA-291639, PHA291639)

货号: PC-42528Not For Human Use, Lab Use Only.

Toceranib (PHA 291639, SU11654) is a potent, ATP-competitive inhibitor of RTKs, including VEGFR, FGFR, PDGFR, and Kit, has Ki of 5 and 6 nM for PDGFRβ and Flk-1/KDR.

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100 mg	￥980	In stock
250 mg		Get quote

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生物&药学活性

Toceranib (PHA 291639, SU11654) is a potent, ATP-competitive inhibitor of RTKs, including VEGFR, FGFR, PDGFR, and Kit, has Ki of 5 and 6 nM for PDGFRβ and Flk-1/KDR.
Toceranib inhibits phosphorylation of WT Kit in the presence of stem cell factor at concentrations as low as 0.01 uM.
Toceranib disrupts function of all forms of mutant Kit in cells.

物理化学性质&存储条件

分子量	396.4579
分子式	C22H25FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrrole-3-carboxamide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-

参考文献

1. Liao AT, et al. Blood. 2002 Jul 15;100(2):585-93.

2. London CA, et al. Clin Cancer Res. 2003 Jul;9(7):2755-68.

3. London C, et al. Vet Comp Oncol. 2012 Sep;10(3):194-205.

Toceranib (PHA 291639, SU11654, SU-11654, PHA-291639, PHA291639)

生物&药学活性

物理化学性质&存储条件

参考文献

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Toceranib (PHA 291639, SU11654, SU-11654, PHA-291639, PHA291639)

生物&药学活性

物理化学性质&存储条件

参考文献

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