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首页-小分子抑制剂&激动剂-Tyrosine Kinase-PDGFR-Toceranib
Toceranib

Chemical Structure : Toceranib

CAS No.: 356068-94-5

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Toceranib (SU 11654;PHA 291639;SU11654;SU-11654;PHA-291639;PHA291639)

货号: PC-42528Not For Human Use, Lab Use Only.

An ATP-competitive inhibitor of RTKs, including VEGFR, FGFR, PDGFR, and Kit.

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50 mg ￥3680 In stock
100 mg ￥6580 In stock
500 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

An ATP-competitive inhibitor of RTKs, including VEGFR, FGFR, PDGFR, and Kit; inhibits phosphorylation of WT Kit in the presence of stem cell factor at concentrations as low as 0.01 uM; disrupts function of all forms of mutant Kit in cells.

物理化学性质&存储条件

分子量 396.4579
分子式 C22H25FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Pyrrole-3-carboxamide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-

参考文献

1. Liao AT, et al. Blood. 2002 Jul 15;100(2):585-93.

2. London CA, et al. Clin Cancer Res. 2003 Jul;9(7):2755-68.

3. London C, et al. Vet Comp Oncol. 2012 Sep;10(3):194-205.

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