欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Tyrosine Kinase-PDGFR-Sunitinib
Sunitinib

Chemical Structure : Sunitinib

CAS No.: 557795-19-4

加入收藏

Sunitinib (SU11248, SU-11248)

货号: PC-42490Not For Human Use, Lab Use Only.

A multi-targeted RTK inhibitor that targets VEGFR2 (Flk-1) and PDGFRβ with Ki of 8 nM and 9 nM respectively.

规格 价格 库存 数量
100 mg ￥580 In stock
250 mg ￥880 In stock
500 mg ￥1380 In stock
1 g Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sunitinib (SU11248) is a multi-targeted RTK inhibitor that targets VEGFR2 (Flk-1) and PDGFRβ with Ki of 8 nM and 9 nM respectively.
Sunitinib displays >10-fold higher selectivity over FGFR-1, EGFR, Cdk2, Met, IGFR-1, Abl, and Src.
Sunitinib also inhibits phosphorylation of wild-type FLT3, FLT3-ITD, and FLT3-Asp835 with IC50 of 250 nM, 50 nM, and 30 nM.
Sunitinib regresses FLT3-ITD tumors in the subcutaneous tumor xenograft model.

物理化学性质&存储条件

分子量 398.4738
分子式 C22H27FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 25 mg/mL
Chemical Name/SMILES

1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-

参考文献

1. Sun L, et al. J Med Chem. 2003 Mar 27;46(7):1116-9.

2. O'Farrell AM, et al. Blood. 2003 May 1;101(9):3597-605.

3. Mendel DB, et al. Clin Cancer Res. 2003 Jan;9(1):327-37.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: