Ansornitinib (ANG-3070, ANG3070)

Chemical Structure : Ansornitinib

CAS No.: 1448874-96-1

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货号: PC-49117Not For Human Use, Lab Use Only.

Ansornitinib (ANG-3070, ANG3070) is an oral fibrokinase inhibitor inhibitor of PDGFR and VEGFR/KDR with high binding affinity, also targets Discoidin Domain Receptors 1 and 2 (DDR1 and DDR2), tyrosine kinase receptors linked to the development of fibrosis in the kidneys and lungs.

规格	价格	库存
5 mg	￥2780	In stock
10 mg	￥4580	In stock
25 mg	￥7980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Ansornitinib (ANG-3070, ANG3070) is an oral fibrokinase inhibitor inhibitor of PDGFR and VEGFR/KDR with high binding affinity, also targets Discoidin Domain Receptors 1 and 2 (DDR1 and DDR2), tyrosine kinase receptors linked to the development of fibrosis in the kidneys and lungs.

Ansornitinib (ANG-3070, ANG3070) exhibits limited interaction with other receptor tyrosine kinases

Ansornitinib (ANG-3070, ANG3070) has demonstrated beneficial effects in chronic kidney disease animal models.

物理化学性质&存储条件

分子量	540.624
分子式	C30H32N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate

参考文献

1. Patent US9040555 B2 2015-05-26.
2. Patent WO2021102161 A1 2021-05-27.
3. Prani Paka, et al. World J Nephrol. 2018 Sep 7;7(5):96-107.