| Cat. No. |
Product Name |
Information |
| PC-20418 |
SLB1122168
Spns2 inhibitor
|
SLB1122168 is a potent, specific inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits Spns2-mediated S1P release with IC50 of 94 nM. |
| PC-20351 |
IMMH002
S1P1 agonist
|
IMMH002 is a potent, selective and orally active S1P1 agonist, IMMH002 can be transformed to IMMH002-P in vivo, IMMH002-P activates S1P1, S1P4, and S1P5 with 12.4, 19.8 and 29.4 nM respectively. |
| PC-49650 |
AM095
LPA1 antagonist
|
AM095 (AM-095) is a potent, selective and orally active lysophosphatidic acid type 1 receptor (LPA1) antagonist with IC50 of 0.98 and 0.73 uM for hLPA1 and mLPA1 in GTP S binding assays, respectively, with no LPA1 agonism. |
| PC-49229 |
H2L5186303
LPA2 antagonist
|
H2L5186303 is a potent, selective LPA2 receptor antagonist with IC50 of 8.9 nM, no significant activity against LPA1 and LPA3 receptors (IC50>1,000 nM), inhibits LPA(2) mediated Erk activation and proliferation of HCT-116 cells. |
| PC-49228 |
UCM-14216
LPA2 antagonist
|
UCM-14216 (UCM14216) is a potent and selective antagonist of type 2 lysophosphatidic acid receptor (LPA2) with KD value of 1.3 nM and IC50 of 1.9 uM. |
| PC-49026 |
ASP1126
S1P1 agonist
|
ASP1126 is a potent, selective and orally active sphingosine-1-phosphate (S1P) agonist with EC50 of 7.12 and 517 nM for hS1P1 and hS1P3 in GTPgS-binding assays, respectively. |
| PC-38763 |
SLF1081851
Spns2 inhibitor
|
SLF1081851 is a potent, in vivo-active inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits S1P release with IC50 of 1.93 uM in HeLa cells. |
| PC-38575 |
CS-2100
S1P1 agonist
|
CS-2100 is a potent, selective, orally active S1P1 agonist with EC50 of 4.0 nM, over 5000-fold selectivity against S1P3. |
| PC-38465 |
CYM-5520
S1PR2 agonist
|
CYM 5520 is a potent, selective sphingosine 1-phosphate receptor 2 (S1PR2) allosteric agonist with EC50 of 480 nM, does not activate other S1P receptors. |
| PC-38431 |
Zectivimod
S1P receptor agonist
|
Zectivimod is a sphingosine-1-phosphate (S1P) receptor agonist. |
| PC-38427 |
Vibozilimod
S1PR1 agonist
|
Vibozilimod (SCD 044) is an orally-available, potent, selective sphingosine-1-phosphate receptor-1 (S1PR1) agonist with EC50 of 0.2 nM. |
| PC-73203 |
ML248
S1P4 agonist
|
ML248 (CYM50308) is a potent and selective S1P4 receptor agonist with EC50 of 37.7 nM-79.1 nM. |
