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首页-小分子抑制剂&激动剂-GPCR-Lysophospholipid Receptor-SLB1122168 hydrochloride
SLB1122168 hydrochloride

Chemical Structure : SLB1122168 hydrochloride

CAS No.: 2764877-96-3

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SLB1122168 hydrochloride (SLB 1122168 hydrochloride)

货号: PC-20419Not For Human Use, Lab Use Only.

SLB1122168 hydrochloride is a potent, specific inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits Spns2-mediated S1P release with IC50 of 94 nM.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: 98.76% (HPLC) Select Batch:

生物&药学活性

SLB1122168 hydrochloride is a potent, specific inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits Spns2-mediated S1P release with IC50 of 94 nM.
SLB1122168 displays no activity agianst Mfsd2b, does not inhibit S1P release from mouse red blood cell at 10 uM.
SLB1122168 (10 and 30 mg/kg, i.p.) significantly and dose-dependently decreased the circulating lymphocytes, a pharmacodynamic indication of Spns2 inhibition, in mice and rats.

物理化学性质&存储条件

分子量 394.00
分子式 C22H36ClN3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-6-Decyl-N-(pyrrolidin-3-ylmethyl)benzo[d]oxazol-2-amine hydrochloride

参考文献

1. Burgio AL, et al. J Med Chem. 2023 Apr 3. doi: 10.1021/acs.jmedchem.3c00149.

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