| Cat. No. |
Product Name |
Information |
| PC-22735 |
KSI-6666
S1P1 antagonist
|
KSI-6666 is a potent and selective competitive antagonist of sphingosine 1-phosphate receptor 1 (S1PR1, S1P1 receptor) with IC50 of 6.4 nM in GTP binding assay, and IC50 of 2.64 nM in in Ca2+ mobilization assays. |
| PC-22065 |
ESB1609
S1P5 agonist
|
ESB1609 is a potent, selective, next-generation S1P5 receptor agonist with EC50 of 70 nM at the human S1P5 receptor, has >700-fold selectivity over human S1P1, S1P2, S1P3, and S1P4 receptors (EC50>5 uM). |
| PC-21751 |
ACT-1016-0707
LPA1 inhibitor
|
ACT-1016-0707 is a potent, selective, and orally active lysophosphatidic acid receptor subtype 1 receptor (LPA1 receptor, LPAR1) antagonist with IC50 of 3.1 nM, highly selective over LPAR2 or LPAR3. |
| PC-21569 |
LPA1 antagonist HL001
LPA1 antagonist
|
HL001 is a novel lysophosphatidic acid 1 (LPA1) receptor antagonist, suppresses fibrosis-associated subpopulations of fibroblasts, exhibits significant anti-fibrotic effects both in murine models and human organoid models. |
| PC-21441 |
NXC736 hydrochloride
S1PR4 inhibitor
|
NXC736 (Vonifimod, SLB736) hydrochloride is a selective functional antagonist for type 4 sphingosine-1-phosphate receptor (S1PR4, S1P4 receptor), has immunomodulatory and anti-fibrotic effects. |
| PC-21440 |
NXC736
S1P4 antagonist
|
NXC736 (Vonifimod, SLB736) is a selective functional antagonist for type 4 sphingosine-1-phosphate receptor (S1P4 receptor, S1P4R), has immunomodulatory and anti-fibrotic effects. |
| PC-21209 |
TY-52156
S1P3 inhibitor
|
TY-52156 is a potent, selective S1P3 receptor antagonist with Ki of 110 nM. |
| PC-21122 |
TP0541640
LPA1 antagonist
|
TP0541640 (TP 0541640) is a novel potent LPA1 antagonist with IC50 of 1.6 nM, shows potential for the treatment of lung and skin fibrosis. |
| PC-20833 |
A-971432
S1P5 agonist
|
A-971432 is a potent, highly selective, CNS-penetrant and orally bioavailable agonist of S1P5 receptor with EC50 values of 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively. |
| PC-20759 |
ONO-0740556
LPA1 agonist
|
ONO-0740556 is a small molecule agonist of lysophosphatidic acid receptor 1 (LPA1) with EC50 of 0.26 nM (human LPA1), ONO-0740556 is an LPA analog with more potent activity against LPA1. |
| PC-20462 |
LPA2 antagonist 58
LPA2 inhibitor
|
LPA2 antagonist 58 is a highly potent and selective LPA2 receptor antagonist with pIC50 of 8.22 (hLPA2) and 8.19 (mLPA2), >1000-fold selectivity over LPA1 receptor. |
| PC-20419 |
SLB1122168 hydrochloride
Spns2 inhibitor
|
SLB1122168 hydrochloride is a potent, specific inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits Spns2-mediated S1P release with IC50 of 94 nM. |
