| Cat. No. |
Product Name |
Information |
| PC-73187 |
S1P5-IN-15
S1P5 antagonist
|
S1P5-IN-15 is a potent, selective, orally active and brain-penetrant S1P5 antagonist with IC50 of 0.1 nM, no effect on S1P1-4. |
| PC-72841 |
ALESIA
S1PR3 agonist
|
ALESIA is a sphingosine-1-phosphate receptor 3 (S1PR3)-G12-biased agonist and selectively induces G12 signal. |
| PC-72368 |
SAR247799
S1P1 agonist
|
SAR247799 is a potent, selective G protein-biased S1P1 agonist with EC50 of 39 and 19 nM in β-arrestin and internalization assays, respectivey. |
| PC-72349 |
BMS-986278
LPA1 antagonist
|
BMS-986278 (BMS986278) is a potent, selective lysophosphatidic acid receptor 1 (LPA1) antagonist with human LPA1 Kb of 6.9 nM. |
| PC-35275 |
SAR-100842
LPA1 antagonist
|
Fipaxalparant (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays. |
| PC-35273 |
TAK-615
LPA1 antagonist
|
TAK-615 (TAK615) is a potent, selective, negative allosteric modulator (NAM) of the LPA1 receptor, partially inhibits the LPA response with IC50 of 91 nM (60% at 10 uM) in calcium mobilisation assays.. |
| PC-35245 |
BMS-986166
S1P modulator
|
BMS-986166 (Udifitimod) is a potent, selective S1P receptor modulator for the treatment of ulcerative colitis. |
| PC-35197 |
ASP6432
LPA1 antagonist
|
ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM. |
| PC-43463 |
Ki16425
LPA1/LPA3 antagonist
|
Ki16425 (Debio 0719) is a potent, subtype-selective, competitive antagonist of lysophosphatidic acid receptor LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, shows no activity at LPA4, LPA5, LPA6. |
| PC-43245 |
S1P1 Agonist 8
S1P1 agonist
|
S1P1 Agonist 8 is a potent, selective, orally bioavailable S1P1 receptor agonist with EC50 of 35 nM (S1P1 internalization), >100-fold selectivity over against receptor subtypes S1P2-5. |
| PC-43209 |
Etrasimod
S1P1 antagonist
|
Etrasimod (APD334) is a potent, selective, centrally available S1P1 receptor antagonist with β-arrestin EC50 of 6.1 nM, internalizes human S1P1 in CHO cells expressing HA tagged S1P1 with IC50 of 1.88 nM. |
| PC-43000 |
Siponimod
S1P1/S1P5 modulator
|
Siponimod (BAF312) is a potent, selective S1P1/S1P5 receptor modulator with EC50 of 0.39/0.0.98 nM, >1,000-fold selectivity over S1P2/3/4. |
