ALESIA | S1PR3 agonist | Probechem Biochemicals

Chemical Structure : ALESIA

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ALESIA (S1PR3 agonist)

货号: PC-72841Not For Human Use, Lab Use Only.

ALESIA is a sphingosine-1-phosphate receptor 3 (S1PR3)-G12-biased agonist and selectively induces G12 signal.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ALESIA is a specific sphingosine-1-phosphate receptor 3 (S1PR3)-G12-biased agonist and selectively induces G12 signal.
ALESIA promotes nitric oxide production and oxidative stress.
ALESIA selectively induces apoptosis in cancer cells because of low glucose levels.
Intraperitoneal administration of ALESIA improved the survival of mice with peritoneally disseminated rhabdomyosarcoma.
ALESIA (Anticancer Ligand Enhancing Starvation-induced Apoptosis) is a new anticancer compound for glucose starvation therapy.

物理化学性质&存储条件

分子量	456.5
分子式	C22H24F4N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-fluoro-N-(2-((4aS,8aR)-octahydroisoquinolin-2(1H)-yl)-5-(trifluoromethyl)phenyl)benzenesulfonamide

参考文献

1. Masayasu Toyomoto, et al. Cell Chem Biol. 2021 Aug 19;28(8):1132-1144.e9.