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首页-小分子抑制剂&激动剂-GPCR-Lysophospholipid Receptor-CS-2100
CS-2100

Chemical Structure : CS-2100

CAS No.: 913827-99-3

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CS-2100 (CS2100)

货号: PC-38575Not For Human Use, Lab Use Only.

CS-2100 is a potent, selective, orally active S1P1 agonist with EC50 of 4.0 nM, over 5000-fold selectivity against S1P3.

规格 价格 库存 数量
10 mg ￥1380 In stock
25 mg ￥2480 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CS-2100 is a potent, selective, orally active S1P1 agonist with EC50 of 4.0 nM, over 5000-fold selectivity against S1P3.
CS-2100 demonstrates in vivo immunosuppressive efficacy in rats on host versus graft reaction with ID(50) value of 0.407mg/kg.
CS-2100 (0.1 and 1 mg/kg, oral) decreased significantly lymphocyte counts in rats.
CS-2100 is efficacious in the adjuvant-induced arthritis model in rats (ID50=0.44 mg/kg).
CS-2100 (0.1 and 1 mg/kg) significant decreases in the cumulative EAE scores in the EAE model.

物理化学性质&存储条件

分子量 461.536
分子式 C25H23N3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-({4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylic acid

参考文献

1. Nakamura T, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1788-92.

2. Nakamura T, et al. Eur J Med Chem. 2012 May;51:92-8.

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