| Cat. No. |
Product Name |
Information |
| PC-27268 |
ASP4058
S1P1/S1P5 agonist
|
ASP4058 is a potent, next-generation S1P receptor agonist selective for S1P1 and S1P5 with EC50 of 7.4 nM and 7.5 nM respectively. |
| PC-27239 |
RO 6842262
LPAR1 antagonist
|
RO 6842262 is a highly selective, orally active lysophosphatidic acid receptor 1 (LPAR1, LPA1) antagonist with IC50 of 25 nM, reduces plasma histamine levels in a murine LPA challenge model. |
| PC-26587 |
TYY-31
S1PR1 agonist
|
TYY-31 is a potent, highly selective sphingosine-1-phosphate receptor 3 (S1PR3) agonist with EC50 of 1.13 pM, with minimal activity against S1PR2/3/5 (EC50 >10 uM). |
| PC-26330 |
Ibrilparant
LPAR1/LPA1 antagonist
|
Ibrilparant is a potent, selective, and orally active lysophosphatidic acid receptor subtype 1 receptor (LPA1 receptor, LPAR1) antagonist. |
| PC-26262 |
CAY10444
S1P3 antagonist
|
CAY10444 (BML-241) is a selective S1P3 receptor antagonist, inhibits S1P-induced calcium mobilization in CHO cells expressing human S1P3 with IC50 of 11.6 uM. |
| PC-25483 |
BMS-986104
S1PR1 modulator
|
BMS-986104 is a potent, selective S1P1 receptor (S1PR1) modulator. |
| PC-24539 |
LPA1 antagonist Compound A
LPA1 antagonist
|
LPA1 antagonist Compound A is a potent, selective, and brain penetrant lysophosphatidic acid receptor 1 (LPA1) antagonist with IC50 of 18.8 nM in 35S-GTPγS binding assays, and IC50 of 12.03 nM in Ca2+ influx assays. |
| PC-24186 |
Sumonerimod
S1P1 agonist
|
Sumonerimod is a potent, selective S1P1 agonist. |
| PC-23816 |
AD2900 hydrochloride
S1P receptor antagonist
|
AD2900 hydrochloride is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively. |
| PC-23691 |
TRV045
S1P1 agonist
|
TRV045 is a potent, selective agonist of sphingosine 1-phosphate receptor 1 (S1PR1, S1P1 receptor) without effects on lymphocyte trafficking, shows potential anti-epileptic effects. |
| PC-23526 |
AUY954 hydrochloride
S1P1 agonist
|
AUY954 hydrochloride is a potent, selective sphingosine-1-phosphate (S1P1) receptor agonist with EC50 of 1.2 nM (hS1P1) and 0.9 nM (mS1P1) in γ-GTPS-binding assays, >280-fold selective over S1P2-5. |
| PC-23525 |
AUY954
S1P1 agonist
|
AUY954 is a potent, selective sphingosine-1-phosphate (S1P1) receptor agonist with EC50 of 1.2 nM (hS1P1) and 0.9 nM (mS1P1) in γ-GTPS-binding assays, >280-fold selective over S1P2-5. |
