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首页-小分子抑制剂&激动剂-GPCR-Lysophospholipid Receptor-RO 6842262
RO 6842262

Chemical Structure : RO 6842262

CAS No.: 1396006-71-5

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RO 6842262 (RO6842262)

货号: PC-27239Not For Human Use, Lab Use Only.

RO 6842262 is a highly selective, orally active lysophosphatidic acid receptor 1 (LPAR1, LPA1) antagonist with IC50 of 25 nM, reduces plasma histamine levels in a murine LPA challenge model.

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5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RO 6842262 is a highly selective, orally active lysophosphatidic acid receptor 1 (LPAR1, LPA1) antagonist with IC50 of 25 nM, reduces plasma histamine levels in a murine LPA challenge model.

物理化学性质&存储条件

分子量 482.54
分子式 C28H26N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-1-(4'-(4-methyl-5-(((1-phenylethoxy)carbonyl)amino)-1H-1,2,3-triazol-1-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid

参考文献

1. Yimin Qian, et al. J Med Chem. 2012 Sep 13;55(17):7920-39.

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