ASP4058 | S1P1/S1P5 agonist | Probechem Biochemicals

Chemical Structure : ASP4058

CAS No.: 952565-91-2

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ASP4058 (ASP-4058)

货号: PC-27268Not For Human Use, Lab Use Only.

ASP4058 is a potent, next-generation S1P receptor agonist selective for S1P1 and S1P5 with EC50 of 7.4 nM and 7.5 nM respectively.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

ASP4058 is a potent, next-generation S1P receptor agonist selective for S1P1 and S1P5 with EC50 of 7.4 nM and 7.5 nM respectively.
ASP4058 stimulates S1P1 and S1P5, and more than 100-times higher concentration than S1P2, S1P3, and S1P4.
ASP4058 activates rS1P1 and rS1P3 comparable to cognate human S1P1 and S1P5 receptors.
ASP4058 reduced the peripheral lymphocyte counts of Lewis rats as a function of dose (ED50 = 0.10 mg/kg 24 h after treatment, oral).
ASP4058 (0.03, 0.1 or 0.3 mg/kg, oral, vehicle: 0.5% methylcellulose) exhibits prophylactic effect on acute monophasic EAE in rats.

物理化学性质&存储条件

分子量	442.32
分子式	C19H12F6N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-{5-[3-(trifluoromethyl)-4-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}phenyl]-1,2,4-oxadiazol-3-yl}-1H-benzimidazole

参考文献

1. Yamamoto R, et al. PLoS One. 2014 Oct 27;9(10):e110819.

2. Yamamoto R, et al. Br J Pharmacol. 2017 Jul;174(13):2085-2101.

ASP4058 (ASP-4058)

生物&药学活性

物理化学性质&存储条件

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ASP4058 (ASP-4058)

生物&药学活性

物理化学性质&存储条件

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