ML248 (CYM50308) | S1P4 agonist | Probechem Biochemicals

Chemical Structure : ML248

CAS No.: 1345858-76-5

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ML248 (CYM50308, ML-248)

货号: PC-73203Not For Human Use, Lab Use Only.

ML248 (CYM50308) is a potent and selective S1P4 receptor agonist with EC50 of 37.7 nM-79.1 nM.

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10 mg	￥2480	In stock
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生物&药学活性

ML248 (CYM50308) is a potent and selective S1P4 receptor agonist with EC50 of 37.7 nM-79.1 nM.
ML248 (CYM50308) is inactive as an agonist against other members of the receptor family, with EC50s >25 μM against S1P1, S1P2, and S1P3 receptors, and an EC50 of 2.1 μM against the S1P5 receptor.
ML248 (CYM50308) is inhibited by an S1P4 receptor-selective antagonist, inactive for agonism in the presence of >3.7 nM selective antagonist and is nontoxic to U2OS cells.
ML248 (CYM50308) increased expression of the chemokine receptor CXCR4 in compound treated CD8+ T lymphocytes.

物理化学性质&存储条件

分子量	405.46
分子式	C20H21F2N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2Z,5Z)-5-((1-(2,4-Difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methylene)-2-((2-methoxyethyl)imino)-3-methylthiazolidin-4-one

参考文献

1. Miguel Guerrero, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Tobias Burkard, et al. Front Immunol. 2021 Aug 24;12:668884.

ML248 (CYM50308, ML-248)

生物&药学活性

物理化学性质&存储条件

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ML248 (CYM50308, ML-248)

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物理化学性质&存储条件

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