ESB1609 | S1P5 agonist | Probechem Biochemicals

Chemical Structure : ESB1609

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ESB1609 (ESB-1609, ESB 1609)

货号: PC-22065Not For Human Use, Lab Use Only.

ESB1609 is a potent, selective, next-generation S1P5 receptor agonist with EC50 of 70 nM at the human S1P5 receptor, has >700-fold selectivity over human S1P1, S1P2, S1P3, and S1P4 receptors (EC50>5 uM).

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生物&药学活性

ESB1609 is a potent, selective, next-generation S1P5 receptor agonist with EC50 of 70 nM at the human S1P5 receptor, has >700-fold selectivity over human S1P1, S1P2, S1P3, and S1P4 receptors (EC50>5 uM).
ESB1609 is classified as a nonsubstrate of P-glycoprotein, the breast cancer resistance protein, and the human organic anion transporting polypeptides 1B1 and 1B3.
ESB1609 can be a potential therapeutic for a variety of neurodegenerative and lysosomal storage diseases.

物理化学性质&存储条件

分子量	438.91
分子式	C24H23ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cis-3-(2-{4-[(4-chlorophenyl)methoxy]phenyl}-4H,5H,6H,7H-[1,3]oxazolo[4,5-c]pyridin-5-yl)cyclobutane-1-carboxylic acid

参考文献

1. Nicholas P France, et al. Clin Pharmacol Drug Dev. 2023 Jun;12(6):625-638.

ESB1609 (ESB-1609, ESB 1609)

生物&药学活性

物理化学性质&存储条件

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ESB1609 (ESB-1609, ESB 1609)

生物&药学活性

物理化学性质&存储条件

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