NXC736 (Vonifimod, SLB736) hydrochloride | S1PR4 inhibitor

Chemical Structure : NXC736 hydrochloride

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NXC736 hydrochloride (Vonifimod, SLB736, NXC-736)

货号: PC-21441Not For Human Use, Lab Use Only.

NXC736 (Vonifimod, SLB736) hydrochloride is a selective functional antagonist for type 4 sphingosine-1-phosphate receptor (S1PR4, S1P4 receptor), has immunomodulatory and anti-fibrotic effects.

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生物&药学活性

NXC736 (Vonifimod, SLB736) hydrochloride is a selective functional antagonist for type 4 sphingosine-1-phosphate receptor (S1PR4, S1P4 receptor), has immunomodulatory and anti-fibrotic effects.
NXC736 (SLB736) selectively binds to S1P1 and S1P4.
NXC736 (SLB736) inhibits inflammasome activation by interfering with the NLRP3-ASC-cleaved caspase-1 interaction, thereby reducing the expression of IL-1β and blocking the fibrotic pathway.
NXC736 (SLB736) is a potent therapeutic agent against radiation-induced lung fibrosis (RILF).

物理化学性质&存储条件

分子量	362.94
分子式	C17H35ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-Propanediol, 2-amino-2-[2-(1-decyl-1H-1,2,3-triazol-4-yl)ethyl]-, hydrochloride

参考文献

1. Sang Yeon Kim, et al. Int J Mol Sci. 2023 Nov 13;24(22):16265.

2. Chung Hwan Hong, et al. Cell Mol Gastroenterol Hepatol. 2022;13(3):925-947.

NXC736 hydrochloride (Vonifimod, SLB736, NXC-736)

生物&药学活性

物理化学性质&存储条件

参考文献

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NXC736 hydrochloride (Vonifimod, SLB736, NXC-736)

生物&药学活性

物理化学性质&存储条件

参考文献

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