AM095 | LPA1 antagonist | Probechem Biochemicals

Chemical Structure : AM095

CAS No.: 1345614-59-6

加入收藏

AM095 (AM-095)

货号: PC-49650Not For Human Use, Lab Use Only.

AM095 (AM-095) is a potent, selective and orally active lysophosphatidic acid type 1 receptor (LPA1) antagonist with IC50 of 0.98 and 0.73 uM for hLPA1 and mLPA1 in GTP S binding assays, respectively, with no LPA1 agonism.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AM095 (AM-095) is a potent, selective and orally active lysophosphatidic acid type 1 receptor (LPA1) antagonist with IC50 of 0.98 and 0.73 uM for hLPA1 and mLPA1 in GTP S binding assays, respectively, with no LPA1 agonism.
AM095 inhibited LPA-driven chemotaxis of CHO cells overexpressing mouse LPA1 (IC50=778 nM) and human A2058 melanoma cells (IC50=233 nM) in function assays.
AM095 inhibited LPA1-driven chemotaxis of both human A2058 melanoma cells (IC50 =0.23 uM) and mouse LPA1/CHO cells (IC50=0.78 uM)。
AM095 dose-dependently reduced LPA-stimulated histamine release, attenuated bleomycin-induced increases in collagen, protein, and inflammatory cell infiltration in bronchalveolar lavage fluid in vivo.
AM095 decreased kidney fibrosis in a mouse unilateral ureteral obstruction model.

物理化学性质&存储条件

分子量	478.48
分子式	C27H23N2NaO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium, {4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-acetate

参考文献

1. Swaney JS, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):693-700.

AM095 (AM-095)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AM095 (AM-095)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.