UCM-14216 | LPA2 antagonist | Probechem Biochemicals

Chemical Structure : UCM-14216

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UCM-14216 (UCM14216)

货号: PC-49228Not For Human Use, Lab Use Only.

UCM-14216 (UCM14216) is a potent and selective antagonist of type 2 lysophosphatidic acid receptor (LPA2) with KD value of 1.3 nM and IC50 of 1.9 uM.

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生物&药学活性

UCM-14216 (UCM14216) is a potent and selective antagonist of type 2 lysophosphatidic acid receptor (LPA2) with KD value of 1.3 nM and IC50 of 1.9 uM.
UCM-14216 displays a selectivity over other LPA receptor subtypes (LPA1 and LPA3-6, with 10-fold selectivity in terms of IC50 value with respect to LPA1 and LPA3 and 10-fold selectivity versus LPA6 and >50-fold selectivity versus LPA4 and LPA5 in terms of KD).
UCM-14216 (25 mg/kg, i.p.) significantly improves motor recovery in an in vivo model of spinal cord injury in an LPA2-dependent manner.

物理化学性质&存储条件

分子量	433.249
分子式	C18H14Cl2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((1H-tetrazol-5-yl)methoxy)-2-(4-(2,4-dichlorophenoxy)-5-methyl-1H-pyrazol-3-yl)phenol

参考文献

1. Nora Khiar-Fernández, et al. J Med Chem. 2022 Aug 25;65(16):10956-10974.

UCM-14216 (UCM14216)

生物&药学活性

物理化学性质&存储条件

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UCM-14216 (UCM14216)

生物&药学活性

物理化学性质&存储条件

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