IMMH002 | S1P1 agonist | Probechem Biochemicals

Chemical Structure : IMMH002

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IMMH002 (IMMH 002)

货号: PC-20351Not For Human Use, Lab Use Only.

IMMH002 is a potent, selective and orally active S1P1 agonist, IMMH002 can be transformed to IMMH002-P in vivo, IMMH002-P activates S1P1, S1P4, and S1P5 with 12.4, 19.8 and 29.4 nM respectively.

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生物&药学活性

IMMH002 is a potent, selective and orally active S1P1 agonist, IMMH002 can be transformed to IMMH002-P in vivo, IMMH002-P activates S1P1, S1P4, and S1P5 with 12.4, 19.8 and 29.4 nM respectively.
IMMH002-P only showed mild activation effect on S1P2 and S1P3 with EC50 >5000 nM.
IMMH002-P induces activation and internalization of S1P1.
IMMH002 (0.3, 1 and 3 mg/kg, p.o.) dramatically decreases the number of peripheral blood lymphocytes, alleviates sodium dodecyl sulphate (SDS)-induced skin irritation in mice in SD rats.
IMMH002 (1.2, 2.4 mg/kg) ameliorates propranolol induced psoriasis in guinea pig.

物理化学性质&存储条件

分子量	366.46
分子式	C22H26N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-2-(2-(4'-(2-ethyloxazol-4-yl)-[1,1'-biphenyl]-4-yl)ethyl)propane-1,3-diol

参考文献

1. Jin J, et al. Acta Pharm Sin B. 2020 Feb;10(2):276-288.

2. Tian Y, et al. MedChemComm. 2013;4:1267.

IMMH002 (IMMH 002)

生物&药学活性

物理化学性质&存储条件

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IMMH002 (IMMH 002)

生物&药学活性

物理化学性质&存储条件

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